←Volver

VERONICA MERICQ GUILA

MEDICO ENDOCRINOLOGÍA INFANTIL
Profesor Titular
Unidad de Endocrinología Infantil y Genética

vmericq@med.uchile.cl
ANEXO 70860

Endocrinóloga infantil y profesora titular del IDIMI. Posterior a su formación en Chile, la Dra. Mericq estuvo dos años como investigador invitado en la unidad de Endocrinología del Desarrollo del NICHD, NIH, EE. UU. La Dra. Mericq ha participado en numerosos proyectos de investigación financiados como coinvestigador e investigador principal. Su principal interés de investigación son las interacciones del crecimiento con el metabolismo de carbohidratos y sensibilidad a la insulina. Tiene 173 publicaciones en revistas especializadas y ha contribuido con siete capítulos en libros de endocrinología. La Dra. Mericq es miembro de ESPE, The Endocrine Society, SLEP, ALAD, ISPAD, SOCHED. Actualmente forma parte del comité científico de la reunión anual de la Endocrine Society y de SLEP, participa en el consejo editorial de JCEM y otras revistas de endocrinología. Participó como delegada de SLEP en el consenso sobre niños nacidos pequeños para la edad gestacional y la resistencia a la insulina en la infancia. La Dra. Mericq ha recibido varios premios durante su carrera, incluyendo Mejor Estudiante de Medicina, Premio ALAD al investigador Joven, Premio a la Trayectoria de Investigación de la Academia Chilena de Medicina, Reconocimiento ESPE a mitad de carrera, Premio César Bergada de SLEP, Premio investigador destacado SOCHED y ESPE en reconocimiento a la excelencia, liderazgo y contribución notable en el campo de la endocrinología pediátrica.

Novel loci and mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys. Vicuña L, Norambuena T, Miranda JP, Pereira A, Mericq V, Ongaro L, Montinaro F, Santos JL, Eyheramendy S.Hum Genet. 2021 May 28. doi: 10.1007/s00439-021-02290-3
Total and Central Adiposity Are Associated With Age at Gonadarche and Incidence of Precocious Gonadarche in Boys Pereira A, Busch AS, Solares F, Baier I, Corvalan C, Mericq V.J Clin Endocrinol Metab. 2021 Apr 23;106(5):1352-1361. doi: 10.1210/clinem/dgab064
Phenotypic continuum between Waardenburg syndrome and idiopathic hypogonadotropic hypogonadism in humans with SOX10 variants Rojas RA, Kutateladze AA, Plummer L, Stamou M, Keefe DL Jr, Salnikov KB, Delaney A, Hall JE, Sadreyev R, Ji F, Fliers E, Gambosova K, Quinton R, Merino PM, Mericq V, Seminara SB, Crowley WF Jr, Balasubramanian R. Genet Med 2021 Apr;23(4):629-636. doi: 10.1038/s41436-020-01051-3.
Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women with Hypothalamic Amenorrhea Delaney A, Burkholder AB, Lavender CA, Plummer L, Mericq V, Merino PM, Quinton R, Lewis KL, Meader BN, Albano A, Shaw ND, Welt CK, Martin KA, Seminara SB, Biesecker LG, Bailey-Wilson JE, Hall JE.J Clin Endocrinol Metab. 2020 Sep 1:dgaa609. doi: 10.1210/clinem/dgaa609
Reproductive hormones during pubertal transition in girls with transient Thelarche Soto J, Pereira A, Siegfried Busch A, Almstrup K, Corvalan C, Iñiguez G, Juul A, Mericq V.Clin Endocrinol (Oxf). 2020 May 17. doi: 10.1111/cen.14248
Neonatal diabetes due to potassium channel mutation: Response to sulfonylurea according to the genotype Garcin L, Mericq V, Fauret-Amsellem AL, Cave H, Polak M, Beltrand Predator Diabetes. 2020 Sep;21(6):932-941. doi: 10.1111/pedi.13041.
Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study Groeneweg S, van Geest FS, Abacı A, Alcantud A, Ambegaonkar GP, Armour CM, Bakhtiani P, Barca D, Bertini ES, van Beynum IM, Brunetti-Pierri N, Bugiani M, Cappa M, Cappuccio G, Castellotti B, Castiglioni C, Chatterjee K, de Coo IFM, Coutant R, Craiu D, Crock P, DeGoede C, Demir K, Dica A, Dimitri P, Dolcetta-Capuzzo A, Dremmen MHG, Dubey R, Enderli A, Fairchild J, Gallichan J, George B, Gevers EF, Hackenberg A, Halász Z, Heinrich B, Huynh T, Kłosowska A, van der Knaap MS, van der Knoop MM, Konrad D, Koolen DA, Krude H, Lawson-Yuen A, Lebl J, Linder-Lucht M, Lorea CF, Lourenço CM, Lunsing RJ, Lyons G, Malikova J, Mancilla EE, McGowan A, Mericq V, Lora FM, Moran C, Müller KE, Oliver-Petit I, Paone L, Paul PG, Polak M, Porta F, Poswar FO, Reinauer C, Rozenkova K, Menevse TS, Simm P, Simon A, Singh Y, Spada M, van der Spek J, Stals MAM, Stoupa A, Subramanian GM, Tonduti D, Turan S, den Uil CA, Vanderniet J, van der Walt A, Wémeau JL, Wierzba J, de Wit MY, Wolf NI, Wurm M, Zibordi F, Zung A, Zwaveling-Soonawala N, Visser WE.Lancet Diabetes Endocrinol. 2020 Jul;8(7):594-605
A Polygenic risk score suggest shared genetic architecture of voice break with early markers of pubertal onset in boys. Lardone MC, Busch AS, Santos JL, Miranda P, Eyheramendy S, Pereira A, Juul A, Almstrup K, Mericq V. J Clin Endocrinol Metab. 2020 Mar 1;105(3).
High DHEAS in girls associates to earlier pubertal maturation, mild increase in androgens throughout puberty without affecting post menarche ovarian morphology, Merino, P, Pereira A, Iñiguez G., Corvalan C., Mericq V. Horm Res Paediatr. 2019;92(6):357-364
Obesity and Related Metabolic Biomarkers and Its Association with Serum Levels of Estrogen in Pre-pubertal Chilean Girls. Mesa Valencia DC, Mericq V, Corvalán C, Pereira A. Endocr Res. 2019 Oct 31:1-9. doi: 10.1080/07435800.201
Childhood Obesity: A Risk Factor for Non-alcoholic Fatty Liver Disease in Adolescence. Benítez VC, Alberti G, Uauy R, Pereira A, García C, de Barbieri F, Corvalán C, Santos JL, Mericq V, Villarroel L, Gana JC. J Pediatr Gastroenterol Nutr. 2019 Oct 23
Psychometric performance of the Quality of Life in Short Stature Youth (QoLISSY) questionnaire in a randomized open-label comparator trial in idiopathic short stature. Bloemeke J, Balacano Valdez R, Mauras N, Mericq V, Ross J, Permuy J, Quitmann J, Bullinger M. J Pediatr Endocrinol Metab. 2019 Oct 25;32(10):1089-1101. doi: 10.1515/jpem-2019-0137.
Age at pubertal development in a Hispanic-Latina Female Population: Should the definitions be revisited? Pereira A, Corvalan C, Merino PM, Leiva V, Mericq V. J Pediatr Adolesc Gynecol. 2019
Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium. Bangalore Krishna K, Fuqua JS, Rogol AD, Klein KO, Popovic J, Houk CP, Charmandari E, Lee PA, Freire AV, Ropelato MG, Yazid Jalaludin M, Mbogo J, Kanaka-Gantenbein C, Luo X, Eugster EA, Klein KO, Vogiatzi MG, Reifschneider K, Bamba V, Garcia Rudaz C, Kaplowitz P, Backeljauw P, Allen DB, Palmert MR, Harrington J, Guerra-Junior G, Stanley T, Torres Tamayo M, Miranda Lora AL, Bajpai A, Silverman LA, Miller BS, Dayal A, Horikawa R, Oberfield S, Rogol AD, Tajima T, Popovic J, Witchel SF, Rosenthal SM, Finlayson C, Hannema SE, Castilla-Peon MF, Mericq V, Medina Bravo PG Horm REs Ped 2019 Jul 18:1-16. doi: 10.1159/000501336.
Glucocorticoids Decrease Longitudinal Bone Growth in Paediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signalling Pathway. Delucchi Á, Toro L, Alzamora R, Barrientos V, González M, Andaur R, León P, Villanueva F, Galindo M, Heras FL, Montecino M, Moena D, Lazcano A, Pinto V, Salas P, Reyes ML, Mericq V, Michea L. J Bone Miner Res. 2019 May 17. doi: 10.1002/jbmr.3761.
Intrauterine twin discordancy followed by partial postnatal catch-up growth in a girl with a pathogenic IGF1R mutation Ocaranza P, Losekoot M, Walenkamp MJE, de Bruin C, Wit JM, Mericq V J Clin Res Pediatr Endocrinol. 2019 Mar 12. doi: 10.4274/jcrpe.galenos.2019.2018.0236.
Quality of Life in Adolescent Boys with Idiopathic Short Stature: Positive Impact of Growth Hormone and Aromatase Inhibitors. Bullinger M, Bloemeke J, Mericq V, Sommer R, Gaete X, Ross JL, Yu YM, Permuy J, Gagliardi P, Damaso YL, Mauras N.Horm Res Paediatr. 2019 Feb 28:1-12. doi: 10.1159/000496353
Klotho gene and protein IN human placentas according to birth weight and gestational age. Iñiguez G, Gallardo P, Castro JJ Gonzalez R, García M, Kakarieka E, San Martín S , Johnson C, Mericq V, Cassorla F, Frontiers of endocrinology , Front Endocrinol (Lausanne). 2019 Jan 15;9:797. doi
Role of the androgen receptor gene CAG repeat polymorphism on the sequence of pubertal events and adiposity in girls with high dehydroepiandrosterone sulfate. Lardone MC, Castro A, Pereira A, Corvalán C, Ortíz E, Mericq V. J Pediatr Adolesc Gynecol. 2018 Dec 11
Is There a Difference between Ultrasonographic (US) Uterine Changes of Oral Versus Transdermal (TD) 17β Estradiol (17β E2) in Girls with Turner Syndrome (TS)? Own Experience and Literature Review. Kraus J, Unanue N, Espinoza A, Iniguez G, Torres-Santiago L, Singh R, Mauras N, Mericq V.Pediatr Endocrinol Rev. 2018 Sep;16(1):178-185.
Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls. Binder AM, Stiemsma LT, Keller K, van Otterdijk SD, Mericq V, Pereira A, Santos JL, Shepherd J, Michels KB.Clin Epigenetics. 2018 Oct 4;10(1):122. doi: 10.1186/s13148-018-0553-5

2019-2023 Investigador Prinicipal, Proyecto FONDECYT Grant N°1190346 " PREMATURE ADRENARCHE : UNANSWERED QUESTIONS"
2014-2018 Investigador Prinicipal, Proyecto FONDECYT grant N° 1140447 PREMATURE ADRENARCHE AND EFFECTS ON OVARIAN FUNCTION, PUBERTAL TEMPO AND METABOLIC RISK
2006- actualidad. Coinvestigador principal en Chile THE MOLECULAR BASIS OF INHERITED REPRODUCTIVE DISORDERS WWW.CLINICALTRIALS.GOV ID# NCT00392756. FUNDING EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT/NATIONAL INSTITUTES OF HEALTH
2011-2014 Coinvestigador, grant WCRF 245/2010, EARLY DETERMINANTS OF BREAST CANCER RISK YEARS FUNDING WCR
2012-2016 Coinvestigador principal en Chile. A RANDOMIZED CONTROLLED TRIAL OF THE USE OF AROMATASE INHIBITORS ALONE AND IN COMBINATION WITH GROWTH HORMONE IN ADOLESCENT BOYS WITH IDIOPATHIC SHORT STATURE NEMOURS FOUNDATION , USA.
2012-2015 Coinvestigador, FONDECYT grant N° 1120326 INTERACTIONS OF EARLY GROWTH, ADIPOSITY AND RATE OF SKELETAL MATURATION IN DETERMINING: TIMING AND PROGRESSION OF PUBERTY AND METABOLIC STATUS OF CHILEAN CHILDREN.
2011-2014 Coinvestigador, FONDECYT grant N° 111 0240 INTRACELLULAR SIGNALING INDUCED BY IGF-I IN HUMAN PRETERM AND TERM PLACENTAS. MODULATION BY THE KLOTHO/FGF SYSTEM ,
2010 -2011 Coinvestigador principal en Chile, ESTROGEN DOSING IN TURNER SYNDROME; PHARMACOLOGY AND METABOLISM. NEMOURS FOUNDATION, USA