La implantación del embrión en el útero materno, es el proceso más crítico y limitante de los tratamientos de reproducción asistida. El embrión se anida en el endometrio en un periodo especifico del ciclo menstrual denominado ventana de implantación. El éxito de la implantación depende del desarrollo óptimo y la calidad del embrión así como de la capacidad del endometrio para permitir su implantación, una característica denominada: receptividad endometrial.
La receptividad endometrial se consigue como consecuencia del desarrollo del endometrio guiado básicamente por las hormonas ováricas estradiol y progesterona. El endometrio receptivo expone características morfológicas, bioquímicas, moleculares y de expresión génica que pueden evaluarse mediante técnicas que se desarrollan en nuestro instituto.
A través de trabajos de investigación en los laboratorios de biología celular y molecular, hemos desarrollado un estudio para evaluar la receptividad endometrial como componente básico de la sincronización en el dialogo embrión-endometrio, necesario para la implantación embrionaria.
El estudio se denomina sincronizar y permite evaluar las características del endometrio con capacidad receptiva para sincronizar su interacción con el embrión y facilitar s implantación.
Las indicaciones del estudio sincronizar incluyen: estudio de receptividad endometrial, falla recurrente de implantación embrionaria, aborto recurrente, preparación endometrial para transferencia embrionaria, endometrio refractario a estimulación hormonal entre otras indicaciones.
Para la realización de este estudio, pueden comunicarse al correo (wapalomino@gmail.com).
Referencias.
-Progesterone receptor is not downregulated in endometrial epithelial compartment during embryo receptivity phase in assisted reproductive cycles WA. Palomino, M.P. Rivas, F. Argandoña, L. Devoto, A. Fuentes, A. Muñoz, F. Gabler, R. Savaris, B. Lessey, C. Johnson . Human Reproduction Volume 36, Suppl July 2021 https://academic.oup.com/humrep
-The endometria from women with recurrent implantation failure exhibit abnormal expression of complement regulatory proteins. Promising immunologic marker of endometrial receptivity.WA. Palomino, C. Aguirre, F. Argandoña, K. Sequeira, L. Devoto JBRA Assisted Reproduction 2017; 21 (2): 142-160 doi: 10.5935/1518-0557.20170031
-The eutopic endometrium from women with endometriosis exhibit decreased levels of complement decay accelerating factor and abnormal expression of progesterone receptor during the implantation window. W.A. Palomino, S. Aguilar, M. Ortiz, F.A. Argandoña, P. Kohen, L. Devoto Placenta 36 (2015) 469e521 http://dx.doi.org/10.1016/j.placenta.2015.01.381
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Un artículo muy informativo sobre la receptividad endometrial, un factor crucial para el éxito de la implantación, similar a los logros de los estudiantes de Telkom University Jakarta.
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